Home / Science / ‘Those unfortunate events:’ Second retraction for stem cell scientist in Canada accused of misconduct – Retraction Watch

‘Those unfortunate events:’ Second retraction for stem cell scientist in Canada accused of misconduct – Retraction Watch

‘Those unfortunate events:’ Second retraction for stem cell scientist in Canada accused of misconduct – Retraction Watch

McMaster’s University Hall, by way of Wikipedia

Citing a misconduct investigation, the journal Stem Cells has retracted a 2009 article coauthored by a researcher whose work has been underneath suspicion for roughly 5 years. 

The paper was titled “Cell adhesion and spreading affect adipogenesis from embryonic stem cells: the role of calreticulin.” The retraction discover, which is behind a paywall, states: 

The above article revealed on June 04, 2009 in STEM CELLS has been retracted by settlement between the Journal Editors and co‐publishers, AlphaMed Press and Wiley Periodicals, Inc. The retraction has been agreed following an investigation carried out by McMaster University (Hamilton ON, Canada) and as a consequence of main overlap with a beforehand revealed article in the Journal of Cell Biology (“Calreticulin inhibits commitment to adipocyte differentiation” by Eva Szabo, Yuanyuan Qiu, Shairaz Baksh, Marek Michalak, and Michal Opas, Volume 182, 2008, pages 103‐16) which the Journal of Cell Biology subsequently retracted (“Retraction of: Calreticulin inhibits commitment to adipocyte differentiation” Volume 208, 2015, web page 249‐50).

The paper has been cited 15 occasions, in keeping with Clarivate Analytics’ Web of Knowledge.

The retraction is the second for Szabo, about whom we wrote in 2015, when the Journal of Cell Biology issued what stays one of essentially the most detailed notices we’ve ever seen. Commenters to that publish famous that Szabo’s work has come underneath scrutiny on PubPeer, the place a number of of her articles — together with, in January 2016, the Stem Cell paper — have been flagged as problematic. 

Another was a 2010 paper in Nature, “Direct conversion of human fibroblasts to multilineage blood progenitors,” which in 2018 obtained the following discover

It has been identified that in Supplementary Fig. 3b of this Article, some gel photos of particular person PCR merchandise have been inaccurately compiled, resulting in duplication of gel photos in lanes the place no band was current. Unfortunately, the information containing the unique PCR photos for Supplementary Figs. 2e and 3b couldn’t be positioned. We have subsequently repeated these experiments utilizing the identical human mobile reagents as initially reported to substantiate our outcomes and conclusions. We present the uncooked photos of gel merchandise, in addition to the move cytometry, human embryoid physique photos, and flowchart of the replication of these experiments, in the Supplementary Information of this Amendment. We thank M. Nakanishi and T. Collins for independently performing these experiments and analysing the outcomes. The authentic Article has not been corrected. 

In 2008, when the JCB article appeared, Szabo had just lately accomplished a PhD on the University of Toronto, the place she’d labored with Michal Opas, of the Department of Laboratory Medicine and Pathobiology. According to her LinkedIn web page, she was an assistant professor at McMaster between 2013 and June 2019, however now works as a “Medical R&D Consultant.” 

We emailed Opas concerning the newest retraction and the misconduct inquiry. He informed us: 

I want to chorus from commenting on these unfortunate occasions.

Michelle Donovan, the supervisor of media relations for McMaster, declined to touch upon the case, citing confidentiality necessities. She referred us as an alternative to the college’s code of conduct.  

We additionally emailed the editor-in-chief of Stem Cells however have but toreceive a reply. 

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